- Antwon Tanner - Antwon "Skills" Taylor
- Brett Claywell - Tim Smith
- Bryan Greenberg - Jake Jagielski
- Chad Michael Murray - Lucas Eugene Scott
- Gregory Harrison - Paul Norris
- Joe Manganiello - Owen Morello
- Kevin Kilner - Larry Sawyer
- Kieren Hutchison - Andy Hargrove
- Lee Norris - Marvin "Mouth" Leonardo McFadden
- Paul Johansson - Daniel "Dan" Robert Scott
- Richard Burgi - Theodore Davis
- Robert Buckley - Clayton "Clay" Evans
- Scott Holroyd - David Fletcher
- Stephen Colleti - Chace Adams
- Tyler Hilton - Chris Keller



- Allison Munn - Miss Lauren Fletcher
- Amanda Schull - Katie Ryan
- Barbara Alyn Woods - Deborah "Deb" Lee Scott
- Bevin Prince - Bevin Evans Mirskey - Smith
- Chelsea Kane - Tara Richard
- Danneel Ackles - Rachel Virginia Gatina - Scott
- Dephne Zuniga - Viktoria Davis
- Emmanuelle Vaugier - Nicki
- Jana Kramer - Alex Dupre
- Kate Vogel - Mia Catalano
- Lisa Goldstein - Millicent "Millie" Huxtebel - McFadden
- Michaela McManus - Lindsey Evelyn Strauss
- Moira Kelly - Karen Roe
- Sharon Laurence - Sylvia Baker